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HomoloGene:56379. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   APP,  H.sapiens
amyloid beta (A4) precursor protein
    NP_000475.1
770 aa
   APP,  P.troglodytes
amyloid beta (A4) precursor protein
    NP_001013036.1
770 aa
   APP,  M.mulatta
amyloid beta (A4) precursor protein
    XP_002803216.1
776 aa
   APP,  C.lupus
amyloid beta (A4) precursor protein
    NP_001006601.1
770 aa
   APP,  B.taurus
amyloid beta (A4) precursor protein
    NP_001070264.1
695 aa
   App,  M.musculus
amyloid beta (A4) precursor protein
    NP_001185752.1
770 aa
   App,  R.norvegicus
amyloid beta (A4) precursor protein
    NP_062161.1
770 aa
   APP,  G.gallus
amyloid beta (A4) precursor protein
    NP_989639.1
751 aa
   app,  X.tropicalis
amyloid beta (A4) precursor protein
    NP_001005698.1
750 aa
   appb,  D.rerio
amyloid beta (A4) precursor protein b
    NP_690842.1
694 aa
   apl-1,  C.elegans
apl-1
    NP_508870.3
686 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Alzheimer disease-1, APP-related.
Amyloidosis, cerebroarterial, Dutch type.
Amyloidosis, cerebroarterial, Iowa type.



Publications
Articles associated with genes and sequences of this homology group.

The profile of β-amyloid precursor protein expression of rats induced by aluminum.
Li XB, et al. Environ Toxicol Pharmacol 33, 135-40 (2012).
Caenorhabditis elegans as a model organism to study APP function.
Ewald CY & Li C. Exp Brain Res 217, 397-411 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Beta-APP (pfam03494)
  Beta-amyloid peptide (beta-APP).
APP_amyloid (pfam10515)
  beta-amyloid precursor protein C-terminus.
APP_Cu_bd (pfam12924)
  Copper-binding of amyloid precursor, CuBD.
APP_E2 (pfam12925)
  E2 domain of amyloid precursor protein.
APP_N (pfam02177)
  Amyloid A4 N-terminal heparin-binding.
KfrA_N (pfam11740)
  Plasmid replication region DNA-binding N-term.
APP_N (pfam02177)
  Amyloid A4 N-terminal heparin-binding.
APP_amyloid (pfam10515)
  beta-amyloid precursor protein C-terminus.
APP_E2 (pfam12925)
  E2 domain of amyloid precursor protein.
KU (cl00101)
  BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus App includes H.sapiens APP and R.norvegicus App.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (14 transcripts, 10 species)
Mammalia - mammals (11 transcripts, 9 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (7 transcripts, 6 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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