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HomoloGene:2428. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TFR2,  H.sapiens
transferrin receptor 2
    NP_003218.2
801 aa
   TFR2,  P.troglodytes
transferrin receptor 2
    XP_003318698.1
801 aa
   TFR2,  M.mulatta
transferrin receptor 2
    XP_001113151.1
672 aa
   TFR2,  C.lupus
transferrin receptor 2
    XP_005621095.1
806 aa
   TFR2,  B.taurus
transferrin receptor 2
    NP_001171212.1
803 aa
   Tfr2,  M.musculus
transferrin receptor 2
    NP_056614.3
798 aa
   Tfr2,  R.norvegicus
transferrin receptor 2
    NP_001099386.1
798 aa
   tfr2,  D.rerio
transferrin receptor 2
    NP_001009916.1
783 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hemochromatosis, type 3.



Publications
Articles associated with genes and sequences of this homology group.

TFR2-Related Hereditary Hemochromatosis
Camaschella C, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TFR_dimer (pfam04253)
  Transferrin receptor-like dimerization domain.
Iap (COG2234)
  Predicted aminopeptidases [General function prediction only].
Zinc_peptidase_like (cl14876)
  Zinc peptidases M18, M20, M28, and M42.
PA (cl08238)
  PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. ...
Zinc_peptidase_like (cl14876)
  Zinc peptidases M18, M20, M28, and M42.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tfr2 includes H.sapiens TFR2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)

 

 

 

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