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HomoloGene:90949. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SEPT9,  H.sapiens
septin 9
    NP_001106963.1
586 aa
   SEPT9,  C.lupus
septin 9
    XP_005624215.1
643 aa
   SEPT9,  B.taurus
septin 9
    XP_003587532.1
585 aa
   Sept9,  M.musculus
septin 9
    NP_001106958.1
583 aa
   Sept9,  R.norvegicus
septin 9
    NP_114025.2
576 aa
   SEPT9,  G.gallus
septin 9
    NP_001025872.1
584 aa
   sept9,  X.tropicalis
septin 9
    XP_002935967.1
576 aa
   sept9a,  D.rerio
septin 9a
    NP_944593.1
584 aa
   CDC10,  S.cerevisiae
CDC10
    NP_009928.1
322 aa
   KLLA0F12848g,  K.lactis
KLLA0F12848g
    XP_455659.1
337 aa
   AGOS_AAR001C,  E.gossypii
AGOS_AAR001C
    NP_982542.1
328 aa
   spn2,  S.pombe
spn2
    NP_593159.1
331 aa
   MGG_06726,  M.oryzae
MGG_06726
    XP_003709437.1
337 aa
   NCU03515,  N.crassa
NCU03515
    XP_955871.1
337 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Amyotrophy, hereditary neuralgic.
neuritis with brachial predilection.
Leukemia, acute myeloid, therapy-related.
Ovarian carcinoma.



Publications
Articles associated with genes and sequences of this homology group.

Septin9 is involved in T-cell development and CD8+ T-cell homeostasis.
Lassen LB, et al. Cell Tissue Res 352, 695-705 (2013).
Alternative exon usage of rat septins.
Jackisch BO, et al. Biochem Biophys Res Commun 275, 180-8 (2000).
Identification of a novel alternatively spliced septin.
Fung ET & Scheller RH. FEBS Lett 451, 203-8 (1999).
Septin9 is involved in septin filament formation and cellular stability.
Füchtbauer A, et al. Biol Chem 392, 769-77 (2011).
Mutations in SEPT9 cause hereditary neuralgic amyotrophy.
Kuhlenbäumer G, et al. Nat Genet 37, 1044-6 (2005).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MCLC (pfam05934)
  Mid-1-related chloride channel (MCLC).
COG1100 (COG1100)
  GTPase SAR1 and related small G proteins [General function prediction only].
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).
AAA_29 (cl17516)
  P-loop containing region of AAA domain.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sept9 includes H.sapiens SEPT9 and R.norvegicus Sept9.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (9 transcripts, 8 species)
Mammalia - mammals (6 transcripts, 5 species)
Aves - birds (3 transcripts, 3 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

 

 

 

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