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HomoloGene:240. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PEX12,  H.sapiens
peroxisomal biogenesis factor 12
    NP_000277.1
359 aa
   PEX12,  P.troglodytes
peroxisomal biogenesis factor 12
    XP_523610.2
359 aa
   PEX12,  C.lupus
peroxisomal biogenesis factor 12
    XP_548259.1
359 aa
   PEX12,  B.taurus
peroxisomal biogenesis factor 12
    NP_001076847.1
359 aa
   Pex12,  M.musculus
peroxisomal biogenesis factor 12
    NP_598786.1
359 aa
   Pex12,  R.norvegicus
peroxisomal biogenesis factor 12
    NP_446373.1
359 aa
   LOC100909787,  R.norvegicus
peroxisome assembly protein 12-like
    XP_006247088.1
359 aa
   PEX12,  G.gallus
peroxisomal biogenesis factor 12
    XP_415773.2
356 aa
   pex12,  X.tropicalis
peroxisomal biogenesis factor 12
    XP_004911685.1
353 aa
   pex12,  D.rerio
peroxisomal biogenesis factor 12
    NP_956499.1
303 aa
   Pex12,  D.melanogaster
Peroxin 12
    NP_608546.1
297 aa
   AgaP_AGAP010497,  A.gambiae
AgaP_AGAP010497
    XP_001237561.2
318 aa
   prx-12,  C.elegans
prx-12
    NP_509908.1
359 aa
   SPAPB17E12.03,  S.pombe
SPAPB17E12.03
    NP_001018219.2
343 aa
   MGG_01771,  M.oryzae
MGG_01771
    XP_003714773.1
453 aa
   NCU05245,  N.crassa
NCU05245
    XP_962009.1
446 aa
   PEX12,  A.thaliana
PEX12
    NP_187096.2
393 aa
   Os10g0467200,  O.sativa
Os10g0467200
    NP_001064809.1
394 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Peroxisome biogenesis factor 12.



Publications
Articles associated with genes and sequences of this homology group.

PEX12 encodes an integral membrane protein of peroxisomes.
Okumoto K & Fujiki Y. Nat Genet 17, 265-6 (1997).
PEX5 binds the PTS1 independently of Hsp70 and the peroxin PEX12.
Harper CC, et al. J Biol Chem 278, 7897-901 (2003).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PTZ00373 (PTZ00373)
  60S Acidic ribosomal protein P2; Provisional.
zf-C3HC4_2 (pfam13923)
  Zinc finger, C3HC4 type (RING finger).
Pex2_Pex12 (pfam04757)
  Pex2 / Pex12 amino terminal region.
Pex2_Pex12 (pfam04757)
  Pex2 / Pex12 amino terminal region.
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pex12 includes H.sapiens PEX12 and R.norvegicus Pex12.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (27 transcripts, 22 species)
Liliopsida - monocots (10 transcripts, 8 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 4 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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