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HomoloGene:5422. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PC,  H.sapiens
pyruvate carboxylase
    NP_071504.2
1178 aa
   PC,  P.troglodytes
pyruvate carboxylase
    XP_003952003.1
2003 aa
   PC,  M.mulatta
pyruvate carboxylase
    XP_001107814.1
1178 aa
   PC,  C.lupus
pyruvate carboxylase
    XP_540825.2
1178 aa
   PC,  B.taurus
pyruvate carboxylase
    NP_808815.2
1178 aa
   Pcx,  M.musculus
pyruvate carboxylase
    NP_001156418.1
1179 aa
   Pc,  R.norvegicus
pyruvate carboxylase
    NP_036876.2
1178 aa
   pc.2,  X.tropicalis
pyruvate carboxylase, gene 2
    NP_001096495.1
401 aa
   pcxb,  D.rerio
pyruvate carboxylase b
    NP_571625.1
1180 aa
   CG1516,  D.melanogaster
CG1516
    NP_724844.1
1197 aa
   AgaP_AGAP004742,  A.gambiae
AgaP_AGAP004742
    XP_001689096.1
1196 aa
   pyc-1,  C.elegans
pyc-1
    NP_001256376.1
1175 aa
   PYC2,  S.cerevisiae
PYC2
    NP_009777.1
1180 aa
   PYC1,  S.cerevisiae
PYC1
    NP_011453.1
1178 aa
   KLLA0C05764g,  K.lactis
KLLA0C05764g
    XP_452456.1
1173 aa
   AGOS_AAR162C,  E.gossypii
AGOS_AAR162C
    NP_982705.2
1171 aa
   pyr1,  S.pombe
pyr1
    NP_595900.1
1185 aa
   MGG_07756,  M.oryzae
MGG_07756
    XP_003712969.1
1197 aa
   NCU02505,  N.crassa
NCU02505
    XP_965636.1
1184 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pyruvate carboxylase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

[Expression and clinical significance of pyruvate carboxylase in gastric adenocarcinoma].
Kang J, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 29, 85-8 (2013).
Pyruvate carboxylase is expressed in human skeletal muscle.
Minet AD & Gaster M. Biochem Biophys Res Commun 402, 196-7 (2010).
Pyruvate Carboxylase Deficiency
Wang D, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CPSase_L_chain (pfam00289)
  Carbamoyl-phosphate synthase L chain, N-terminal domain.
ATP-grasp_4 (cl03087)
  ATP-grasp domain.
ATP-grasp_4 (pfam13535)
  ATP-grasp domain.
CPSase_L_chain (pfam00289)
  Carbamoyl-phosphate synthase L chain, N-terminal domain.
PYC_OADA (pfam02436)
  Conserved carboxylase domain.
Med15 (pfam09606)
  ARC105 or Med15 subunit of Mediator complex non-fungal.
Biotin_carb_C (cl08365)
  Biotin carboxylase C-terminal domain.
Biotinyl_lipoyl_domains (cl11404)
  Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, ...
ATP-grasp_4 (cl17255)
  ATP-grasp domain.
DRE_TIM_metallolyase (cl18962)
  DRE-TIM metallolyase superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pcx includes H.sapiens PC and R.norvegicus Pc.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (20 transcripts, 10 species)
Mammalia - mammals (15 transcripts, 10 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 10 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (17 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (2 transcripts, 2 species)
Eudicotyledons - eudicots (1 transcript, 1 species)
Coniferopsida - conifers (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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