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HomoloGene:74460. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   SPTA1,  H.sapiens
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
2419 aa
   SPTA1,  P.troglodytes
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
2419 aa
   SPTA1,  M.mulatta
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
2420 aa
   SPTA1,  C.lupus
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
2352 aa
   SPTA1,  B.taurus
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
2411 aa
   Spta1,  M.musculus
spectrin alpha, erythrocytic 1
2415 aa
   Spta1,  R.norvegicus
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
2416 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Spherocytosis, recessive.

Articles associated with genes and sequences of this homology group.

[Spectrin--variety of functions hidden in the structure].
Wolny M, et al. Postepy Biochem 58, 245-54 (2012).
On the association of lipid rafts to the spectrin skeleton in human erythrocytes.
Ciana A, et al. Biochim Biophys Acta 1808, 183-90 (2011).
Vascular dysfunction in a murine model of severe hemolysis.
Frei AC, et al. Blood 112, 398-405 (2008).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Spectrin (pfam00435)
  Spectrin repeat.
efhand_Ca_insen (pfam08726)
  Ca2+ insensitive EF hand.
FRQ1 (COG5126)
  Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only].
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
SH3 (cl17036)
  Src Homology 3 domain superfamily.
EFhand_Ca_insen (pfam08726)
  Ca2+ insensitive EF hand.
Spectrin (cl02488)
  Spectrin repeat.
SH3 (cl17036)
  Src Homology 3 domain superfamily.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Spta1 includes H.sapiens SPTA1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

Polychaeta - segmented worms (1 transcript, 1 species)




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