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HomoloGene:14586. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MMAA,  H.sapiens
methylmalonic aciduria (cobalamin deficiency) cblA type
    NP_758454.1
418 aa
   MMAA,  P.troglodytes
methylmalonic aciduria (cobalamin deficiency) cblA type
    XP_526697.2
418 aa
   MMAA,  C.lupus
methylmalonic aciduria (cobalamin deficiency) cblA type
    XP_539752.4
428 aa
   MMAA,  B.taurus
methylmalonic aciduria (cobalamin deficiency) cblA type
    NP_001093812.1
421 aa
   Mmaa,  M.musculus
methylmalonic aciduria (cobalamin deficiency) type A
    NP_598584.2
415 aa
   Mmaa,  R.norvegicus
methylmalonic aciduria (cobalamin deficiency) cblA type
    NP_001099644.1
415 aa
   MMAA,  G.gallus
methylmalonic aciduria (cobalamin deficiency) cblA type
    XP_420429.1
412 aa
   mmaa,  X.tropicalis
methylmalonic aciduria (cobalamin deficiency) cblA type
    XP_002938979.1
409 aa
   mmaa,  D.rerio
methylmalonic aciduria (cobalamin deficiency) cblA type
    NP_001098582.1
403 aa
   mmaa-1,  C.elegans
mmaa-1
    NP_001022302.1
399 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Methylmalonic aciduria, vitamin B12-responsive.



Publications
Articles associated with genes and sequences of this homology group.

Spondylocostal dysostosis associated with methylmalonic aciduria.
Honjo RS, et al. Genet Test Mol Biomarkers 13, 181-3 (2009).
Protection and reactivation of human methylmalonyl-CoA mutase by MMAA protein.
Takahashi-Íñiguez T, et al. Biochem Biophys Res Commun 404, 443-7 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).
NK (cl17190)
  Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
Fer4_NifH (cl17203)
  The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mmaa includes H.sapiens MMAA and R.norvegicus Mmaa.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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