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HomoloGene:55607. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   COL2A1,  H.sapiens
collagen, type II, alpha 1
    NP_001835.3
1487 aa
   COL2A1,  P.troglodytes
collagen, type II, alpha 1
    XP_509026.2
1487 aa
   COL2A1,  M.mulatta
collagen, type II, alpha 1
    XP_001100739.1
1487 aa
   COL2A1,  C.lupus
collagen, type II, alpha 1
    NP_001006952.1
1487 aa
   COL2A1,  B.taurus
collagen, type II, alpha 1
    NP_001001135.2
1487 aa
   Col2a1,  M.musculus
collagen, type II, alpha 1
    NP_112440.2
1487 aa
   Col2a1,  R.norvegicus
collagen, type II, alpha 1
    NP_037061.1
1419 aa
   COL2A1,  G.gallus
collagen, type II, alpha 1
    NP_989757.1
1420 aa
   col2a1,  X.tropicalis
collagen, type II, alpha 1
    NP_989220.1
1492 aa
   col2a1a,  D.rerio
collagen type II, alpha-1a
    NP_571367.1
1491 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Stickler syndrome, type I.
Vitreoretinopathy with phalangeal epiphyseal dysplasia.
Epiphyseal dysplasia, multiple, with myopia and deafness.
Platyspondylic skeletal dysplasia, Torrance type.
Kniest dysplasia.
Osteoarthrosis.
SED congenita.
SMED Strudwick type.
SMD.
Spondyloperipheral dysplasia.
Achondrogenesis-hypochondrogenesis, type II.
Otospondylomegaepiphyseal dysplasia.
Spondyloperipheral dysplasia.
Avascular necrosis of the femoral head.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
VWC (pfam00093)
  von Willebrand factor type C domain.
COLFI (cl02436)
  Fibrillar collagen C-terminal domain.
VWC (cl17735)
  von Willebrand factor type C domain.
Collagen (cl19732)
  Collagen triple helix repeat (20 copies).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Col2a1 includes H.sapiens COL2A1 and R.norvegicus Col2a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (25 transcripts, 12 species)
Actinopterygii - bony fishes (24 transcripts, 9 species)
Cephalochordata - lancelets (4 transcripts, 1 species)
Hyperoartia - vertebrates (4 transcripts, 1 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (4 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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