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HomoloGene:12746. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KRIT1,  H.sapiens
KRIT1, ankyrin repeat containing
    NP_004903.2
736 aa
   KRIT1,  P.troglodytes
KRIT1, ankyrin repeat containing
    XP_001166722.1
736 aa
   KRIT1,  M.mulatta
KRIT1, ankyrin repeat containing
    XP_001101416.1
736 aa
   KRIT1,  C.lupus
KRIT1, ankyrin repeat containing
    XP_539416.2
736 aa
   KRIT1,  B.taurus
KRIT1, ankyrin repeat containing
    NP_001001166.1
736 aa
   Krit1,  M.musculus
KRIT1, ankyrin repeat containing
    NP_109600.2
736 aa
   Krit1,  R.norvegicus
KRIT1, ankyrin repeat containing
    NP_001102088.1
736 aa
   KRIT1,  G.gallus
KRIT1, ankyrin repeat containing
    NP_001026144.1
737 aa
   krit1,  X.tropicalis
KRIT1, ankyrin repeat containing
    NP_001121439.1
743 aa
   krit1,  D.rerio
KRIT1, ankyrin repeat containing
    NP_955866.1
442 aa
   kri-1,  C.elegans
kri-1
    NP_001021863.1
729 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cavernous malformations of CNS and retina.
Cerebral cavernous malformations-1.
Hyperkeratotic cutaneous capillary-venous malformations associated with cerebral capillary malformations.



Publications
Articles associated with genes and sequences of this homology group.

Ccm1 assures microvascular integrity during angiogenesis.
Liu H, et al. Transl Stroke Res 1, 146-53 (2010).
Ccm1 regulates microvascular morphogenesis during angiogenesis.
Liu H, et al. J Vasc Res 48, 130-40 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
B41 (smart00295)
  Band 4.1 homologues.
FERM_M (pfam00373)
  FERM central domain.
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
FERM_M (pfam00373)
  FERM central domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Krit1 includes H.sapiens KRIT1 and R.norvegicus Krit1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 11 species)
Actinopterygii - bony fishes (14 transcripts, 9 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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