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HomoloGene:20558. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   MYL4,  H.sapiens
myosin, light chain 4, alkali; atrial, embryonic
197 aa
   MYL4,  P.troglodytes
myosin, light chain 4, alkali; atrial, embryonic
193 aa
   LOC717354,  M.mulatta
myosin light chain 4-like
195 aa
   MYL4,  C.lupus
myosin, light chain 4, alkali; atrial, embryonic
191 aa
   MYL4,  B.taurus
myosin, light chain 4, alkali; atrial, embryonic
193 aa
   Myl4,  M.musculus
myosin, light polypeptide 4
193 aa
   Myl4,  R.norvegicus
myosin, light chain 4
193 aa
   MYL4,  G.gallus
myosin, light chain 4, alkali; atrial, embryonic
185 aa
   myl4,  X.tropicalis
myosin, light chain 4, alkali; atrial, embryonic
190 aa
   myl4,  D.rerio
myosin, light chain 4, alkali; atrial, embryonic
187 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Myosin essential light chain in health and disease.
Hernandez OM, et al. Am J Physiol Heart Circ Physiol 292, H1643-54 (2007).
Human atrial myosin light chain 1 expression attenuates heart failure.
Abdelaziz AI, et al. Adv Exp Med Biol 565, 283-92; discussion 92, 405-15 (2005).
Tuning the human heart molecular motors by myosin light chains.
Morano I. J Mol Med (Berl) 77, 544-55 (1999).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myl4 includes H.sapiens MYL4.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (27 transcripts, 10 species)
Mammalia - mammals (10 transcripts, 9 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)




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