Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:32032. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   BSCL2,  H.sapiens
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
    NP_001116427.1
462 aa
   LOC100609080,  P.troglodytes
seipin-like
    XP_003313147.1
462 aa
   BSCL2,  M.mulatta
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
    XP_002799560.1
468 aa
   BSCL2,  C.lupus
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
    XP_853538.1
456 aa
   BSCL2,  B.taurus
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
    NP_001015589.1
394 aa
   Bscl2,  M.musculus
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
    NP_001129536.1
443 aa
   Bscl2,  R.norvegicus
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
    NP_001012171.1
377 aa
   bscl2,  D.rerio
Bernardinelli-Seip congenital lipodystrophy 2 (seipin)
    NP_001032473.1
350 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Lipodystrophy, congenital generalized, type 2.
Silver spastic paraplegia syndrome.
Neuropathy, distal hereditary motor, type V.
Spinal muscular atrophy, distal, type V.



Publications
Articles associated with genes and sequences of this homology group.

A new seipin-associated neurodegenerative syndrome.
Guillén-Navarro E, et al. J Med Genet 50, 401-9 (2013).
Motor neuron degeneration in a mouse model of seipinopathy.
Guo J, et al. Cell Death Dis 4, e535 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TFIIFa (cl15395)
  Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA ...
Seipin (pfam06775)
  Putative adipose-regulatory protein (Seipin).
PHA00666 (PHA00666)
  putative protease.
DARPP-32 (pfam05395)
  Protein phosphatase inhibitor 1/DARPP-32.
Seipin (pfam06775)
  Putative adipose-regulatory protein (Seipin).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bscl2 includes H.sapiens BSCL2 and R.norvegicus Bscl2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 13 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

 

 

 

Write to the Help Desk