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HomoloGene:7420. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   MESP2,  H.sapiens
mesoderm posterior 2 homolog (mouse)
397 aa
   MESP2,  P.troglodytes
mesoderm posterior 2 homolog (mouse)
389 aa
   MESP2,  M.mulatta
mesoderm posterior 2 homolog (mouse)
373 aa
   MESP2,  C.lupus
mesoderm posterior 2 homolog (mouse)
270 aa
   MESP2,  B.taurus
mesoderm posterior 2 homolog (mouse)
367 aa
   Mesp2,  M.musculus
mesoderm posterior 2
370 aa
   Mesp2,  R.norvegicus
mesoderm posterior 2 homolog (mouse)
368 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Spondylocostal dysostosis, autosomal recessive 2.

Articles associated with genes and sequences of this homology group.

Role of autophagy in cancer: management of metabolic stress.
Jin S & White E. Autophagy 3, 28-31 (2007).
Mutated MESP2 causes spondylocostal dysostosis in humans.
Whittock NV, et al. Am J Hum Genet 74, 1249-54 (2004).
Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression.
Yasuhiko Y, et al. Proc Natl Acad Sci U S A 103, 3651-6 (2006).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mesp2 includes H.sapiens MESP2 and R.norvegicus Mesp2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (5 transcripts, 5 species)
Aves - birds (1 transcript, 1 species)




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