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HomoloGene:2635. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PLA2G6,  H.sapiens
phospholipase A2, group VI (cytosolic, calcium-independent)
    NP_003551.2
806 aa
   PLA2G6,  P.troglodytes
phospholipase A2, group VI (cytosolic, calcium-independent)
    XP_003317276.1
806 aa
   PLA2G6,  M.mulatta
phospholipase A2, group VI (cytosolic, calcium-independent)
    XP_002798434.1
823 aa
   PLA2G6,  C.lupus
phospholipase A2, group VI (cytosolic, calcium-independent)
    XP_861095.2
836 aa
   PLA2G6,  B.taurus
phospholipase A2, group VI (cytosolic, calcium-independent)
    XP_002687969.2
846 aa
   Pla2g6,  M.musculus
phospholipase A2, group VI
    NP_001185952.1
807 aa
   Pla2g6,  R.norvegicus
phospholipase A2, group VI (cytosolic, calcium-independent)
    NP_001005560.1
807 aa
   PLA2G6,  G.gallus
phospholipase A2, group VI (cytosolic, calcium-independent)
    NP_001124210.1
796 aa
   pla2g6,  X.tropicalis
phospholipase A2, group 6 (cytosolic, calcium-independent)
    NP_001072661.1
399 aa
   pla2g6,  D.rerio
phospholipase A2, group VI (cytosolic, calcium-independent)
    NP_998262.1
818 aa
   iPLA2-VIA,  D.melanogaster
calcium-independent phospholipase A2 VIA
    NP_648366.2
877 aa
   AgaP_AGAP004812,  A.gambiae
AgaP_AGAP004812
    XP_317997.3
893 aa
   CELE_W07A8.2,  C.elegans
CELE_W07A8.2
    NP_508000.1
1023 aa
   F47A4.5,  C.elegans
F47A4.5
    NP_509647.1
1071 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Infantile neuroaxonal dystrophy 1.
Karak syndrome.
Neurodegeneration with brain iron accumulation.



Publications
Articles associated with genes and sequences of this homology group.

Antipsychotic drugs decrease iPLA2 gene expression in schizophrenia.
Kerr DS, et al. Schizophr Res 147, 203-4 (2013).
Four novel rare mutations of PLA2G6 in Chinese population with Parkinson's disease.
Gui YX, et al. Parkinsonism Relat Disord 19, 21-6 (2013).
Role of calcium-independent phospholipase A(2)β in human pancreatic islet β-cell apoptosis.
Lei X, et al. Am J Physiol Endocrinol Metab 303, E1386-95 (2012).
PLA2G6 mutations in PARK14-linked young-onset parkinsonism and sporadic Parkinson's disease.
Lu CS, et al. Am J Med Genet B Neuropsychiatr Genet 159B, 183-91 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Patatin_and_cPLA2 (cl11396)
  Patatins and Phospholipases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pla2g6 includes H.sapiens PLA2G6 and R.norvegicus Pla2g6.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Ascomycota
Pezizomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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