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HomoloGene:37718. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SDHD,  H.sapiens
succinate dehydrogenase complex, subunit D, integral membrane protein
    NP_002993.1
159 aa
   SDHD,  P.troglodytes
succinate dehydrogenase complex, subunit D, integral membrane protein
    XP_508756.1
159 aa
   SDHD,  M.mulatta
succinate dehydrogenase complex, subunit D, integral membrane protein
    XP_001107882.1
159 aa
   SDHD,  C.lupus
succinate dehydrogenase complex, subunit D, integral membrane protein
    XP_536573.3
159 aa
   SDHD,  B.taurus
succinate dehydrogenase complex, subunit D, integral membrane protein
    NP_776604.1
158 aa
   Sdhd,  M.musculus
succinate dehydrogenase complex, subunit D, integral membrane protein
    NP_080124.1
159 aa
   Sdhd,  R.norvegicus
succinate dehydrogenase complex, subunit D, integral membrane protein
    NP_942083.1
159 aa
   SDHD,  G.gallus
succinate dehydrogenase complex, subunit D, integral membrane protein
    NP_001006321.1
157 aa
   sdhd,  X.tropicalis
succinate dehydrogenase complex, subunit D, integral membrane protein
    NP_989357.1
152 aa
   sdhdb,  D.rerio
succinate dehydrogenase complex, subunit D, integral membrane protein b
    NP_001004004.1
158 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Carcinoid tumors, intestinal.
Paragangliomas, familial nonchromaffin, 1, with or without deafness.
Pheochromocytoma.
Merkel cell carcinoma, somatic.



Publications
Articles associated with genes and sequences of this homology group.

The endemic paraganglioma syndrome type 1: origin, spread, and clinical expression.
Schiavi F, et al. J Clin Endocrinol Metab 97, E637-41 (2012).
Genomic imprinting at a boundary element flanking the SDHD locus.
Baysal BE, et al. Hum Mol Genet 20, 4452-61 (2011).
A novel SDHD mutation associated with neck paraganglioma.
Reboll R, et al. Acta Otolaryngol 131, 1110-6 (2011).
Succinate dehydrogenase gene variants and their role in Cowden syndrome.
Bayley JP. Am J Hum Genet 88, 674-5; author reply 676 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SQR_QFR_TM (cl00881)
  Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sdhd includes H.sapiens SDHD and R.norvegicus Sdhd.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (21 transcripts, 15 species)
Actinopterygii - bony fishes (11 transcripts, 10 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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