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HomoloGene:68441. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   MED12,  H.sapiens
mediator complex subunit 12
2177 aa
   MED12,  P.troglodytes
mediator complex subunit 12
2027 aa
   MED12,  M.mulatta
mediator complex subunit 12
2178 aa
   MED12,  C.lupus
mediator complex subunit 12
2176 aa
   MED12,  B.taurus
mediator complex subunit 12
2176 aa
   Med12,  M.musculus
mediator complex subunit 12
2190 aa
   Med12,  R.norvegicus
mediator complex subunit 12
2187 aa
   MED12,  G.gallus
mediator complex subunit 12
2322 aa
   med12,  X.tropicalis
mediator complex subunit 12
2221 aa
   med12,  D.rerio
mediator of RNA polymerase II transcription, subunit 12 homolog
2173 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Opitz-Kaveggia syndrome.

Articles associated with genes and sequences of this homology group.

MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors.
Schwetye KE, et al. Hum Pathol 45, 65-70 (2014).
Exomic landscape of MED12 mutation-negative and -positive uterine leiomyomas.
Mäkinen N, et al. Int J Cancer 134, 1008-12 (2014).
Mutations in MED12 cause X-linked Ohdo syndrome.
Vulto-van Silfhout AT, et al. Am J Hum Genet 92, 401-6 (2013).
MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors.
Markowski DN, et al. Genes Chromosomes Cancer 52, 297-304 (2013).
MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.
Ravegnini G, et al. Mod Pathol 26, 743-9 (2013).
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.
Kämpjärvi K, et al. Br J Cancer 107, 1761-5 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Med12 (pfam09497)
  Transcription mediator complex subunit Med12.
Med12-PQL (pfam12144)
  Eukaryotic Mediator 12 catenin-binding domain.
Med12-LCEWAV (pfam12145)
  Eukaryotic Mediator 12 subunit domain.
Med12-PQL (pfam12144)
  Eukaryotic Mediator 12 catenin-binding domain.
Med12-LCEWAV (pfam12145)
  Eukaryotic Mediator 12 subunit domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Med12 includes H.sapiens MED12 and R.norvegicus LOC679693.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (24 transcripts, 12 species)
Actinopterygii - bony fishes (18 transcripts, 7 species)
Aves - birds (8 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Chromadorea - nematodes (1 transcript, 1 species)

Eudicotyledons - eudicots (1 transcript, 1 species)




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