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HomoloGene:37447. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   ANGPT1,  H.sapiens
angiopoietin 1
498 aa
   ANGPT1,  P.troglodytes
angiopoietin 1
419 aa
   ANGPT1,  M.mulatta
angiopoietin 1
498 aa
   ANGPT1,  C.lupus
angiopoietin 1
497 aa
   ANGPT1,  B.taurus
angiopoietin 1
497 aa
   Angpt1,  M.musculus
angiopoietin 1
498 aa
   Angpt1,  R.norvegicus
angiopoietin 1
497 aa
   ANGPT1,  G.gallus
angiopoietin 1
498 aa
   angpt1,  X.tropicalis
angiopoietin 1
504 aa
   angpt1,  D.rerio
angiopoietin 1
513 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Targeted glomerular angiopoietin-1 therapy for early diabetic kidney disease.
Dessapt-Baradez C, et al. J Am Soc Nephrol 25, 33-42 (2014).
Structural basis for angiopoietin-1-mediated signaling initiation.
Yu X, et al. Proc Natl Acad Sci U S A 110, 7205-10 (2013).
Significant decrease in maternal serum concentrations of angiopoietin-1 and -2 after delivery.
Keikkala E, et al. Acta Obstet Gynecol Scand 91, 917-22 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF1690 (pfam07956)
  Protein of Unknown function (DUF1690).
GAS (pfam13851)
  Growth-arrest specific micro-tubule binding.
FReD (cl00085)
  Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Angpt1 includes H.sapiens ANGPT1 and R.norvegicus Angpt1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 9 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)




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