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HomoloGene:37248. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   A2M,  H.sapiens
alpha-2-macroglobulin
    NP_000005.2
1474 aa
   A2M,  P.troglodytes
alpha-2-macroglobulin
    XP_001139819.1
1474 aa
   A2M,  M.mulatta
alpha-2-macroglobulin
    XP_001114328.1
1474 aa
   A2M,  C.lupus
alpha-2-macroglobulin
    XP_534893.3
1475 aa
   A2M,  B.taurus
alpha-2-macroglobulin
    NP_001103265.1
1510 aa
   A2m,  M.musculus
alpha-2-macroglobulin
    NP_783327.2
1474 aa
   A2m,  R.norvegicus
alpha-2-macroglobulin
    NP_036620.2
1472 aa
   LOC100911545,  R.norvegicus
alpha-2-macroglobulin-like
    XP_003749876.1
1472 aa
   A2M,  G.gallus
alpha-2-macroglobulin
    XP_416476.3
1479 aa
   LOC100489060,  X.tropicalis
alpha-2-macroglobulin-like
    XP_002938549.2
1482 aa
   a2m,  X.tropicalis
alpha-2-macroglobulin
    XP_002938550.2
2947 aa
   LOC100003785,  D.rerio
alpha-2-macroglobulin-P-like
    XP_005157599.1
1437 aa
   zgc:165518,  D.rerio
zgc:165518
    NP_001093623.2
1455 aa
   sb:cb37,  D.rerio
sb:cb37
    XP_001345541.5
1442 aa
   si:dkey-52d15.2,  D.rerio
si:dkey-52d15.2
    XP_001345569.3
1410 aa
   a2ml,  D.rerio
alpha-2-macroglobulin-like
    NP_001132951.1
1442 aa
   LOC100006925,  D.rerio
alpha-2-macroglobulin-like
    XP_001921577.3
970 aa
   LOC100006895,  D.rerio
alpha-2-macroglobulin-like
    XP_001923676.1
1442 aa
   LOC100006782,  D.rerio
alpha-2-macroglobulin-like
    XP_001345438.5
1440 aa
   a2ml1,  D.rerio
alpha-2-macroglobulin-like 1
    XP_697477.6
1479 aa
   zgc:171426,  D.rerio
zgc:171426
    XP_003198073.1
1463 aa
   si:dkey-46g23.5,  D.rerio
si:dkey-46g23.5
    NP_001188334.1
1467 aa
   si:dkey-46g23.2,  D.rerio
si:dkey-46g23.2
    XP_001332356.1
1458 aa
   zgc:171446,  D.rerio
zgc:171446
    NP_001108028.1
1453 aa
   zgc:171445,  D.rerio
zgc:171445
    NP_001107101.1
1459 aa
   zgc:165453,  D.rerio
zgc:165453
    XP_001918704.3
1450 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Emphysema due to alpha-2-macroglobulin deficiency.
Alzheimer disease, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Serum monomeric α2-macroglobulin as a clinical biomarker in diabetes.
Takada T, et al. Atherosclerosis 228, 270-6 (2013).
Inhibition of Aeromonas sobria serine protease (ASP) by α2-macroglobulin.
Murakami Y, et al. Biol Chem 393, 1193-200 (2012).
α-2-Macroglobulin: a physiological guardian.
Rehman AA, et al. J Cell Physiol 228, 1665-75 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MFS (cd06174)
  The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
SVA (pfam05326)
  Seminal vesicle autoantigen (SVA).
A2M_recep (pfam07677)
  A-macroglobulin receptor.
A2M (pfam00207)
  Alpha-2-macroglobulin family.
A2M_N (pfam01835)
  MG2 domain.
A2M_N_2 (pfam07703)
  Alpha-2-macroglobulin family N-terminal region.
MG1 (pfam11974)
  Alpha-2-macroglobulin MG1 domain.
ISOPREN_C2_like (cl08267)
  This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
A2M (pfam00207)
  Alpha-2-macroglobulin family.
A2M_recep (pfam07677)
  A-macroglobulin receptor.
MG1 (pfam11974)
  Alpha-2-macroglobulin MG1 domain.
ISOPREN_C2_like (cl08267)
  This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
Big_1 (cl17740)
  Bacterial Ig-like domain (group 1).
A2M_N (cl19929)
  MG2 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus A2m includes H.sapiens A2M and R.norvegicus A2m.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 12 species)
Actinopterygii - bony fishes (5 transcripts, 2 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

 

 

 

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