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HomoloGene:23770. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SLX4,  H.sapiens
SLX4 structure-specific endonuclease subunit
    NP_115820.2
1834 aa
   SLX4,  P.troglodytes
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
    XP_510772.2
1834 aa
   SLX4,  M.mulatta
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
    XP_001094220.2
1982 aa
   SLX4,  C.lupus
SLX4 structure-specific endonuclease subunit
    XP_005621673.1
1733 aa
   SLX4,  B.taurus
SLX4 structure-specific endonuclease subunit
    XP_002697931.2
1754 aa
   Slx4,  M.musculus
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
    NP_803423.2
1565 aa
   Slx4,  R.norvegicus
SLX4 structure-specific endonuclease subunit
    XP_006245897.1
1732 aa
   SLX4,  G.gallus
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
    XP_414962.4
1863 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
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Publications
Articles associated with genes and sequences of this homology group.

Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families.
Fernández-Rodríguez J, et al. BMC Cancer 12, 84 (2012).
Mutation analysis of the SLX4/FANCP gene in hereditary breast cancer.
Landwehr R, et al. Breast Cancer Res Treat 130, 1021-8 (2011).
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.
Yamamoto KN, et al. Proc Natl Acad Sci U S A 108, 6492-6 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BTB (pfam00651)
  BTB/POZ domain.
Slx4 (pfam09494)
  Slx4 endonuclease.
BTB (cl02518)
  BTB/POZ domain.
VDE (cl06253)
  Violaxanthin de-epoxidase (VDE).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slx4 includes H.sapiens SLX4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (3 transcripts, 3 species)

 

 

 

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