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HomoloGene:156. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HGD,  H.sapiens
homogentisate 1,2-dioxygenase
    NP_000178.2
445 aa
   HGD,  P.troglodytes
homogentisate 1,2-dioxygenase
    XP_001164938.1
445 aa
   HGD,  M.mulatta
homogentisate 1,2-dioxygenase
    XP_001110996.1
445 aa
   HGD,  C.lupus
homogentisate 1,2-dioxygenase
    XP_535754.3
445 aa
   HGD,  B.taurus
homogentisate 1,2-dioxygenase
    NP_001138324.1
445 aa
   Hgd,  M.musculus
homogentisate 1, 2-dioxygenase
    NP_038575.2
445 aa
   Hgd,  R.norvegicus
homogentisate 1, 2-dioxygenase
    NP_001012145.1
445 aa
   HGD,  G.gallus
homogentisate 1,2-dioxygenase
    XP_416553.1
439 aa
   hgd,  X.tropicalis
homogentisate 1,2-dioxygenase
    XP_004912503.1
457 aa
   hgd,  D.rerio
homogentisate 1,2-dioxygenase
    NP_694498.2
443 aa
   hgo,  D.melanogaster
homogentisate 1,2-dioxygenase
    NP_523544.2
439 aa
   AgaP_AGAP009609,  A.gambiae
AgaP_AGAP009609
    XP_318638.4
437 aa
   hgo-1,  C.elegans
hgo-1
    NP_492433.1
437 aa
   MGG_00431,  M.oryzae
MGG_00431
    XP_003718640.1
503 aa
   NCU05499,  N.crassa
NCU05499
    XP_960461.1
467 aa
   HGO,  A.thaliana
HGO
    NP_851187.1
461 aa
   Os06g0103300,  O.sativa
Os06g0103300
    NP_001056540.1
470 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Alkaptonuria.



Publications
Articles associated with genes and sequences of this homology group.

An update on molecular genetics of Alkaptonuria (AKU).
Zatkova A. J Inherit Metab Dis 34, 1127-36 (2011).
Alkaptonuria
Introne WJ, et al. (1993).
Mutation spectrum of homogentisic acid oxidase (HGD) in alkaptonuria.
Vilboux T, et al. Hum Mutat 30, 1611-9 (2009).
R58fs mutation in the HGD gene in a family with alkaptonuria in the UAE.
Abdulrazzaq YM, et al. Ann Hum Genet 73, 125-30 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HgmA (cl17306)
  homogentisate 1,2-dioxygenase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hgd includes H.sapiens HGD and R.norvegicus Hgd.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (11 transcripts, 10 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 8 species)
Arachnida - arachnids (6 transcripts, 2 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (36 transcripts, 31 species)
Liliopsida - monocots (12 transcripts, 8 species)
Coniferopsida - conifers (6 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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