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HomoloGene:149. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MSH6,  H.sapiens
mutS homolog 6
    NP_000170.1
1360 aa
   MSH6,  P.troglodytes
mutS homolog 6 (E. coli)
    XP_003309101.1
1399 aa
   MSH6,  M.mulatta
mutS homolog 6 (E. coli)
    XP_001113749.1
1360 aa
   MSH6,  C.lupus
mutS homolog 6
    XP_531814.2
1283 aa
   MSH6,  B.taurus
mutS homolog 6 (E. coli)
    NP_001179666.1
1360 aa
   Msh6,  M.musculus
mutS homolog 6 (E. coli)
    NP_034960.1
1358 aa
   LOC100360342,  R.norvegicus
mutS homolog 6
    XP_006239796.1
1368 aa
   MSH6,  G.gallus
mutS homolog 6 (E. coli)
    XP_419359.3
1345 aa
   msh6,  X.tropicalis
mutS homolog 6
    XP_002935421.2
1338 aa
   msh6,  D.rerio
mutS homolog 6 (E. coli)
    NP_878280.1
1369 aa
   Msh6,  D.melanogaster
Msh6
    NP_648755.1
1190 aa
   AgaP_AGAP003190,  A.gambiae
AgaP_AGAP003190
    XP_312887.5
1290 aa
   msh-6,  C.elegans
msh-6
    NP_491163.1
1186 aa
   MSH6,  S.cerevisiae
MSH6
    NP_010382.3
1242 aa
   KLLA0C17732g,  K.lactis
KLLA0C17732g
    XP_452992.1
1194 aa
   AGOS_AGR116W,  E.gossypii
AGOS_AGR116W
    NP_986782.2
1167 aa
   msh6,  S.pombe
msh6
    NP_588344.1
1254 aa
   MGG_00704,  M.oryzae
MGG_00704
    XP_003718302.1
1218 aa
   NCU08135,  N.crassa
NCU08135
    XP_959678.2
1237 aa
   MSH6,  A.thaliana
MSH6
    NP_192116.1
1324 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cancer susceptibility.
Colorectal cancer, hereditary nonpolyposis, type 5.
Endometrial carcinoma.
Ovarian cancer, endometrial type.



Publications
Articles associated with genes and sequences of this homology group.

MSH6 mutation in a family affected by Muir-Torre syndrome.
Kacerovska D, et al. Am J Dermatopathol 34, 648-52 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P-loop_NTPase (cl09099)
  P-loop containing Nucleoside Triphosphate Hydrolases.
MutS_V (pfam00488)
  MutS domain V.
MutS_I (pfam01624)
  MutS domain I.
MutS_III (pfam05192)
  MutS domain III.
MutS_II (pfam05188)
  MutS domain II.
CDC27 (pfam09507)
  DNA polymerase subunit Cdc27.
PWWP (cl02554)
  The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.
MutS_I (pfam01624)
  MutS domain I.
MutS_II (pfam05188)
  MutS domain II.
PWWP (cl02554)
  The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
TUDOR (cl02573)
  Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.
MutS_III (cl17822)
  This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam01624 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with domain III, which is central to the structure of Thermus aquaticus MutS as characterized in.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Msh6 includes H.sapiens MSH6.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 12 species)
Actinopterygii - bony fishes (11 transcripts, 10 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (15 transcripts, 11 species)
Liliopsida - monocots (2 transcripts, 2 species)
Coniferopsida - conifers (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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