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HomoloGene:80210. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RPTOR,  H.sapiens
regulatory associated protein of MTOR, complex 1
    NP_065812.1
1335 aa
   RPTOR,  P.troglodytes
regulatory associated protein of MTOR, complex 1
    XP_003953266.1
1336 aa
   RPTOR,  M.mulatta
regulatory associated protein of MTOR, complex 1
    XP_001110471.1
1335 aa
   RPTOR,  C.lupus
regulatory associated protein of MTOR, complex 1
    XP_850487.1
1335 aa
   RPTOR,  B.taurus
regulatory associated protein of MTOR, complex 1
    NP_001179059.1
1335 aa
   Rptor,  M.musculus
regulatory associated protein of MTOR, complex 1
    NP_083174.2
1335 aa
   Rptor,  R.norvegicus
regulatory associated protein of MTOR, complex 1
    NP_001127971.2
1335 aa
   RPTOR,  G.gallus
regulatory associated protein of MTOR, complex 1
    XP_426232.2
1335 aa
   rptor,  X.tropicalis
regulatory associated protein of MTOR, complex 1
    NP_001123843.1
1288 aa
   rptor,  D.rerio
regulatory associated protein of MTOR, complex 1
    XP_005157411.1
1363 aa
   raptor,  D.melanogaster
raptor
    NP_572294.2
1621 aa
   AgaP_AGAP010035,  A.gambiae
AgaP_AGAP010035
    XP_001689178.1
1295 aa
   KOG1,  S.cerevisiae
KOG1
    NP_012056.1
1557 aa
   KLLA0A09471g,  K.lactis
KLLA0A09471g
    XP_451414.1
1506 aa
   AGOS_ADR331C,  E.gossypii
AGOS_ADR331C
    NP_984427.2
1561 aa
   mip1,  S.pombe
mip1
    NP_593370.1
1313 aa
   MGG_02874,  M.oryzae
MGG_02874
    XP_003720858.1
1544 aa
   NCU00621,  N.crassa
NCU00621
    XP_965761.1
1414 aa
   RAPTOR2,  A.thaliana
RAPTOR2
    NP_195797.3
1336 aa
   RAPTOR1,  A.thaliana
RAPTOR1
    NP_566335.1
1344 aa
   Os12g0110000,  O.sativa
Os12g0110000
    NP_001065961.1
1242 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity.
Berezhnoy A, et al. J Clin Invest 124, 188-97 (2014).
A critical role for Rictor in T lymphopoiesis.
Tang F, et al. J Immunol 189, 1850-7 (2012).
mTORC1 is essential for leukemia propagation but not stem cell self-renewal.
Hoshii T, et al. J Clin Invest 122, 2114-29 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HEAT_2 (pfam13646)
  HEAT repeats.
COG2319 (COG2319)
  FOG: WD40 repeat [General function prediction only].
ARM (cd00020)
  Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
ARM (cl02500)
  Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
WD40 (cl02567)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
HEAT (pfam02985)
  HEAT repeat.
HEAT_2 (pfam13646)
  HEAT repeats.
Raptor_N (pfam14538)
  Raptor N-terminal CASPase like domain.
HEAT_EZ (cl02500)
  The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rptor includes H.sapiens RPTOR and R.norvegicus Rptor.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (46 transcripts, 29 species)
Liliopsida - monocots (12 transcripts, 8 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (9 transcripts, 5 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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