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HomoloGene:55938. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MDH2,  H.sapiens
malate dehydrogenase 2, NAD (mitochondrial)
    NP_005909.2
338 aa
   MDH2,  P.troglodytes
malate dehydrogenase 2, NAD (mitochondrial)
    XP_001156205.1
338 aa
   LOC719983,  M.mulatta
malate dehydrogenase, mitochondrial-like
    XP_001114888.1
374 aa
   MDH2,  C.lupus
malate dehydrogenase 2, NAD (mitochondrial)
    XP_849944.1
338 aa
   LOC102152275,  C.lupus
malate dehydrogenase, mitochondrial-like
    XP_005634130.1
411 aa
   Mdh2,  M.musculus
malate dehydrogenase 2, NAD (mitochondrial)
    NP_032643.2
338 aa
   Mdh2,  R.norvegicus
malate dehydrogenase 2, NAD (mitochondrial)
    NP_112413.2
338 aa
   MDH2,  G.gallus
malate dehydrogenase 2, NAD (mitochondrial)
    XP_415765.1
351 aa
   mdh2,  X.tropicalis
malate dehydrogenase 2, NAD (mitochondrial)
    NP_001011412.1
338 aa
   mdh2,  D.rerio
malate dehydrogenase 2, NAD (mitochondrial)
    NP_998296.1
337 aa
   Mdh2,  D.melanogaster
Malate dehydrogenase 2
    NP_650696.1
336 aa
   AgaP_AGAP001903,  A.gambiae
AgaP_AGAP001903
    XP_321163.4
337 aa
   mdh-2,  C.elegans
mdh-2
    NP_498457.1
341 aa
   MDH1,  S.cerevisiae
MDH1
    NP_012838.1
334 aa
   KLLA0F25960g,  K.lactis
KLLA0F25960g
    XP_456236.1
338 aa
   AGOS_ADR152C,  E.gossypii
AGOS_ADR152C
    NP_984248.1
332 aa
   SPCC306.08c,  S.pombe
SPCC306.08c
    NP_587816.1
341 aa
   MGG_09367,  M.oryzae
MGG_09367
    XP_003720254.1
336 aa
   NCU04899,  N.crassa
NCU04899
    XP_958408.1
336 aa
   mMDH1,  A.thaliana
mMDH1
    NP_564625.1
341 aa
   mMDH2,  A.thaliana
mMDH2
    NP_188120.1
341 aa
   Os01g0649100,  O.sativa
Os01g0649100
    NP_001043717.1
340 aa
   Os05g0574400,  O.sativa
Os05g0574400
    NP_001056389.1
340 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Acceleration of adipogenic differentiation via acetylation of malate dehydrogenase 2.
Kim EY, et al. Biochem Biophys Res Commun 441, 77-82 (2013).
Adriamycin induced myocardial failure in rats: protective role of Centella asiatica.
Gnanapragasam A, et al. Mol Cell Biochem 294, 55-63 (2007).
Tom20-mediated mitochondrial protein import in muscle cells during differentiation.
Grey JY, et al. Am J Physiol Cell Physiol 279, C1393-400 (2000).
Aggregation states of mitochondrial malate dehydrogenase.
Sánchez SA, et al. Protein Sci 7, 2184-9 (1998).
Effect of alpha-tocopherol on mitochondrial electron transport in experimental myocardial infarction in rats.
Ithayarasi AP & Shyamala Devi C. Indian J Biochem Biophys 35, 115-9 (1998).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PLN00106 (PLN00106)
  malate dehydrogenase.
LDH_MDH_like (cl17195)
  NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mdh2 includes H.sapiens MDH2 and R.norvegicus Mdh2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (59 transcripts, 35 species)
Liliopsida - monocots (31 transcripts, 9 species)
Coniferopsida - conifers (9 transcripts, 3 species)
Bryopsida - mosses (5 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (5 transcripts, 2 species)

Chordata
Mammalia - mammals (20 transcripts, 18 species)
Actinopterygii - bony fishes (17 transcripts, 11 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (25 transcripts, 12 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (9 transcripts, 3 species)
Pezizomycetes - ascomycetes (2 transcripts, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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