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HomoloGene:497. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LTA,  H.sapiens
lymphotoxin alpha
    NP_000586.2
205 aa
   LTA,  P.troglodytes
lymphotoxin alpha (TNF superfamily, member 1)
    NP_001038975.1
205 aa
   LTA,  M.mulatta
lymphotoxin alpha (TNF superfamily, member 1)
    NP_001040613.1
205 aa
   LTA,  C.lupus
lymphotoxin alpha
    XP_848886.2
204 aa
   LTA,  B.taurus
lymphotoxin alpha (TNF superfamily, member 1)
    NP_001013419.1
204 aa
   Lta,  M.musculus
lymphotoxin A
    NP_034865.1
202 aa
   Lta,  R.norvegicus
lymphotoxin alpha
    NP_542947.1
202 aa
   lta,  X.tropicalis
lymphotoxin alpha
    NP_001107150.1
204 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Myocardial infarction, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Genetic variation in cytokine-related genes and migraine susceptibility.
Stuart S, et al. Twin Res Hum Genet 16, 1079-86 (2013).
TNF-β +252 A>G polymorphism and susceptibility to cancer.
Yang L, et al. J Cancer Res Clin Oncol 139, 765-72 (2013).
Association between the lymphotoxin-alpha gene polymorphism and chagasic cardiopathy.
Pissetti CW, et al. J Interferon Cytokine Res 33, 130-5 (2013).
Investigation of lymphotoxin α genetic variants in migraine.
Oikari LE, et al. Gene 512, 527-31 (2013).
The lymphotoxin-α 252A>G polymorphism and breast cancer: a meta-analysis.
Zhou P, et al. Asian Pac J Cancer Prev 13, 1949-52 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TNF (cl00147)
  Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lta includes H.sapiens LTA and R.norvegicus Lta.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)

 

 

 

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