1: HomoloGene:4911. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SNTB2,  Homo sapiens
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
    NP_006741.1
540 aa
Domain ImageDomain Image
   SNTB2,  Pan troglodytes
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
    XP_001147485.1
318 aa
Domain Image
   SNTB2,  Canis lupus familiaris
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
    XP_536806.2
568 aa
Domain ImageDomain Image
   SNTB2,  Bos taurus
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
    NP_001098936.1
540 aa
Domain ImageDomain Image
   Sntb2,  Mus musculus
syntrophin, basic 2
    NP_033255.1
520 aa
Domain ImageDomain Image
   Sntb2,  Rattus norvegicus
syntrophin, basic 2
    XP_001071043.1
565 aa
Domain ImageDomain Image
   SNTB2,  Gallus gallus
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
    XP_001232942.1
390 aa
Domain ImageDomain Image
   LOC571747,  Danio rerio
similar to beta-2-syntrophin
    XP_001919076.1
449 aa
Domain ImageDomain Image


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenrate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.


  Mus musculus
 
Normal phenotype.
 
Nervous system phenotype.
 
Behavior/neurological phenotype. The observable actions or reactions of mammalian organisms that are manifested through development and lifespan.



PubMed
Articles associated with genes and sequences of this entry plus additional related articles.

 
Mills KA, et al.
A syntrophin gene maps to mouse chromosome 8 and is not the myodystrophy gene. Mamm Genome 6, 664-5(1995).
 
Trajkovski M, et al.
Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512. J Biol Chem 283, 33719-29(2008).
 
Abramovici H & Gee SH.
Morphological changes and spatial regulation of diacylglycerol kinase-zeta, syntrophins, and Rac1 during myoblast fusion. Cell Motil Cytoskeleton 64, 549-67(2007).
 
Adams ME, et al.
Structural abnormalities at neuromuscular synapses lacking multiple syntrophin isoforms. J Neurosci 24, 10302-9(2004).
 
Jones KJ, et al.
Deficiency of the syntrophins and alpha-dystrobrevin in patients with inherited myopathy. Neuromuscul Disord 13, 456-67(2003).
 

 


Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.

 
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...
 
PH-like (cl00273)
  Pleckstrin homology-like domain. This family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but...
 
ThiC (cl08031)
  ThiC family.



Related Homology Resources
Links to curated and computed homology information found in other databases.

 
Orthology group for M.musculus Sntb2 includes H.sapiens SNTB2 and R.norvegicus Sntb2.



UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.

 
Syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component...
 
Syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component...
 
Similar to beta2-syntrophin
 
Syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component...
 
Transcribed locus, weakly similar to NP_033255.1 syntrophin, basic 2 [Mus mu...
 
Syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component...
 
Brain cDNA clone: QflA-10265, similar to human syntrophin, beta 2 (dystrophi...
 
Syntrophin, basic 2
 
Transcribed locus, strongly similar to NP_033255.1 syntrophin, basic 2 [Mus ...
 
Transcribed locus, weakly similar to NP_033255.1 syntrophin, basic 2 [Mus mu...
 
Transcribed locus, strongly similar to NP_033255.1 syntrophin, basic 2 [Mus ...
 
Hypothetical protein LOC100145613