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HomoloGene:4037. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   IDH3A,  H.sapiens
isocitrate dehydrogenase 3 (NAD+) alpha
    NP_005521.1
366 aa
   IDH3A,  P.troglodytes
isocitrate dehydrogenase 3 (NAD+) alpha
    XP_510524.3
366 aa
   IDH3A,  M.mulatta
isocitrate dehydrogenase 3 (NAD+) alpha
    XP_001106839.2
366 aa
   IDH3A,  C.lupus
isocitrate dehydrogenase 3 (NAD+) alpha
    XP_536213.2
366 aa
   IDH3A,  B.taurus
isocitrate dehydrogenase 3 (NAD+) alpha
    NP_777069.1
366 aa
   Idh3a,  M.musculus
isocitrate dehydrogenase 3 (NAD+) alpha
    NP_083849.1
366 aa
   Idh3a,  R.norvegicus
isocitrate dehydrogenase 3 (NAD+) alpha
    NP_446090.1
366 aa
   IDH3A,  G.gallus
isocitrate dehydrogenase 3 (NAD+) alpha
    NP_001005808.1
370 aa
   idh3a,  X.tropicalis
isocitrate dehydrogenase 3 (NAD+) alpha
    NP_989352.1
366 aa
   idh3a,  D.rerio
isocitrate dehydrogenase 3 (NAD+) alpha
    NP_957245.2
365 aa
   l(1)G0156,  D.melanogaster
lethal (1) G0156
    NP_001259705.1
377 aa
   AgaP_AGAP002728,  A.gambiae
AgaP_AGAP002728
    XP_312198.5
354 aa
   idha-1,  C.elegans
idha-1
    NP_492330.2
358 aa
   IDH2,  S.cerevisiae
IDH2
    NP_014779.1
369 aa
   KLLA0E03125g,  K.lactis
KLLA0E03125g
    XP_454086.1
368 aa
   AGOS_AFR137C,  E.gossypii
AGOS_AFR137C
    NP_985684.1
367 aa
   idh2,  S.pombe
idh2
    NP_595203.2
379 aa
   MGG_01712,  M.oryzae
MGG_01712
    XP_003714707.1
385 aa
   NCU07697,  N.crassa
NCU07697
    XP_962283.1
379 aa
   IDH-V,  A.thaliana
IDH-V
    NP_568113.1
374 aa
   IDH-VI,  A.thaliana
IDH-VI
    NP_850549.1
374 aa
   Os01g0276100,  O.sativa
Os01g0276100
    NP_001042725.1
362 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Isocitrate dehydrogenase from bovine heart: primary structure of subunit 3/4.
Zeng Y, et al. Biochem J 310 ( Pt 2), 507-16 (1995).
Basis for half-site ligand binding in yeast NAD(+)-specific isocitrate dehydrogenase.
Lin AP & McAlister-Henn L. Biochemistry 50, 8241-50 (2011).
Disulfide bond formation in yeast NAD+-specific isocitrate dehydrogenase.
Garcia JA, et al. Biochemistry 48, 8869-78 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Iso_dh (cl00445)
  Isocitrate/isopropylmalate dehydrogenase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Idh3a includes H.sapiens IDH3A and R.norvegicus Idh3a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (16 transcripts, 11 species)
Mammalia - mammals (15 transcripts, 15 species)
Ascidiacea - tunicates (6 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (18 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (46 transcripts, 32 species)
Liliopsida - monocots (13 transcripts, 9 species)
Coniferopsida - conifers (5 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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