HomoloGene Result

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HomoloGene:38148. Gene conserved in Coelomata

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.		Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	NCK1, H.sapiens NCK adaptor protein 1		NP_006144.1 377 aa
	NCK1, P.troglodytes NCK adaptor protein 1		XP_001154556.1 377 aa
	NCK1, C.lupus NCK adaptor protein 1		XP_852038.1 377 aa
	NCK1, B.taurus NCK adaptor protein 1		NP_001069540.1 377 aa
	Nck1, M.musculus non-catalytic region of tyrosine kinase adaptor protein 1		NP_035008.2 377 aa
	Nck1, R.norvegicus NCK adaptor protein 1		XP_217246.3 313 aa
	LOC100334953, D.rerio NCK adaptor protein 1-like		XP_002666641.1 381 aa
	dock, D.melanogaster dreadlocks		NP_722657.1 548 aa
	AgaP_AGAP010135, A.gambiae AGAP010135-PA		XP_319290.3 391 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

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Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*M.musculus*
MP:0002873 Normal phenotype.
MP:0003631 Nervous system phenotype.
MP:0005367 Renal/urinary system phenotype.
MP:0005376 Homeostasis/metabolism phenotype.
MP:0005378 Growth/size phenotype.
MP:0005380 Embryogenesis phenotype.
MP:0005384 Cellular phenotype.
MP:0005386 Behavior/neurological phenotype. The observable actions or reactions of mammalian organisms that are manifested through development and lifespan.

PubMed Articles associated with genes and sequences of this homology group.
Essential role of the adaptor protein Nck1 in Jurkat T cell activation and function. Yiemwattana I, et al. Clin Exp Immunol 167, 99-107 (2012).
Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice. Latreille M, et al. Am J Physiol Endocrinol Metab 300, E423-34 (2011).
Interaction between the N-terminal SH3 domain of Nck-alpha and CD3-epsilon-derived peptides: non-canonical and canonical recognition motifs. Santiveri CM, et al. Biochim Biophys Acta 1794, 110-7 (2009).
Enteropathogenic Escherichia coli O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of Nck and TccP/TccP2. Bai L, et al. Infect Immun 76, 361-8 (2008).
Nck-1 selectively modulates eIF2alphaSer51 phosphorylation by a subset of eIF2alpha-kinases. Cardin E, et al. FEBS J 274, 5865-75 (2007).
Dissecting Nck/Dock signaling pathways in Drosophila visual system. Rao Y. Int J Biol Sci 1, 80-6 (2005).
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells. Gruenheid S, et al. Nat Cell Biol 3, 856-9 (2001).
Domain requirements for the Dock adapter protein in growth- cone signaling. Rao Y & Zipursky SL. Proc Natl Acad Sci U S A 95, 2077-82 (1998).
Cloning, sequencing, and overexpression of SH2/SH3 adaptor protein Nck from mouse thymus. Park D. Mol Cells 7, 231-6 (1997).
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Lu W, et al. Curr Biol 7, 85-94 (1997).
See all (219)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
SH2 (cl00138) Src homology 2 domains; Signal transduction, involved in recognition of phosphorylated tyrosine (pTyr). SH2 domains typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2...
SH3 (cl09950) Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization...

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:109601 Orthology group for M.musculus Nck1 includes H.sapiens NCK1 and R.norvegicus Nck1.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Chordata*
Mammalia - mammals (18 transcripts, 13 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
*Arthropoda*
Insecta - insects (6 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
*Cnidaria*
Anthozoa - anthozoans (1 transcript, 1 species)

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