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HomoloGene:30969. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TYR,  H.sapiens
tyrosinase
    NP_000363.1
529 aa
   TYR,  P.troglodytes
tyrosinase (oculocutaneous albinism IA)
    XP_001136041.1
529 aa
   TYR,  M.mulatta
tyrosinase (oculocutaneous albinism IA)
    XP_001105033.1
530 aa
   TYR,  C.lupus
tyrosinase (oculocutaneous albinism IA)
    NP_001002941.1
530 aa
   TYR,  B.taurus
tyrosinase (oculocutaneous albinism IA)
    NP_851344.1
530 aa
   Tyr,  M.musculus
tyrosinase
    NP_035791.1
533 aa
   Tyr,  R.norvegicus
tyrosinase
    NP_001101005.1
530 aa
   TYR,  G.gallus
tyrosinase (oculocutaneous albinism IA)
    NP_989491.1
529 aa
   tyr,  X.tropicalis
tyrosinase
    NP_001096518.1
531 aa
   tyr,  D.rerio
tyrosinase
    NP_571088.1
535 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Waardenburg syndrome/albinism, digenic.
Albinism, oculocutaneous, type IA.
Albinism, oculocutaneous, type IB.



Publications
Articles associated with genes and sequences of this homology group.

Global patterns of diversity and selection in human tyrosinase gene.
Hudjashov G, et al. PLoS One 8, e74307 (2013).
[Effect of zibuganshenfang on the expression and activity of tyrosinase on B16 cells].
Zhao J, et al. Zhongguo Zhong Yao Za Zhi 36, 2567-70 (2011).
[Study of tyrosinase gene mutation in oculocutaneous albinism type 1 patients].
Zheng H, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi 27, 329-32 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tyrosinase (pfam00264)
  Common central domain of tyrosinase.
Tyrosinase (pfam00264)
  Common central domain of tyrosinase.
EGF_Lam (cl19065)
  Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tyr includes H.sapiens TYR and R.norvegicus Tyr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

 

 

 

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