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HomoloGene:273. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   PRPH2,  H.sapiens
peripherin 2 (retinal degeneration, slow)
346 aa
   PRPH2,  P.troglodytes
peripherin 2 (retinal degeneration, slow)
346 aa
   PRPH2,  M.mulatta
peripherin 2 (retinal degeneration, slow)
346 aa
   PRPH2,  C.lupus
peripherin 2 (retinal degeneration, slow)
346 aa
   PRPH2,  B.taurus
peripherin 2 (retinal degeneration, slow)
346 aa
   Prph2,  M.musculus
peripherin 2
346 aa
   Prph2,  R.norvegicus
peripherin 2
346 aa
   PRPH2,  G.gallus
peripherin 2 (retinal degeneration, slow)
354 aa
   prph2,  X.tropicalis
peripherin 2 (retinal degeneration, slow)
349 aa
   prph2a,  D.rerio
peripherin 2a (retinal degeneration, slow)
345 aa
   prph2b,  D.rerio
peripherin 2b (retinal degeneration, slow)
342 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Retinitis punctata albescens.
Butterfly dystrophy, retinal.
Macular dystrophy.
Retinitis pigmentosa, digenic.
Retinitis pigmentosa-7.
Foveomacular dystrophy, adult-onset, with choroidal neovascularization.
Macular dystrophy, vitelliform.

Articles associated with genes and sequences of this homology group.

Cone structure in retinal degeneration associated with mutations in the peripherin/RDS gene.
Duncan JL, et al. Invest Ophthalmol Vis Sci 52, 1557-66 (2011).
Diagnostic and therapeutic challenges.
Genead MA, et al. Retina 31, 413-8 (2011).
The function of oligomerization-incompetent RDS in rods.
Chakraborty D, et al. Adv Exp Med Biol 664, 39-46 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
tetraspanin_LEL (cl02781)
  Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
TDT (cl04176)
  The Tellurite-resistance/Dicarboxylate Transporter (TDT) family.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prph2 includes H.sapiens PRPH2 and R.norvegicus Prph2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (7 transcripts, 6 species)
Actinopterygii - bony fishes (6 transcripts, 4 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)




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