HomoloGene Result

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HomoloGene:20225. Gene conserved in Euteleostomi

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.		Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	GRIA2, H.sapiens glutamate receptor, ionotropic, AMPA 2		NP_000817.2 883 aa
	GRIA2, P.troglodytes glutamate receptor, ionotropic, AMPA 2		NP_001171923.2 883 aa
	GRIA2, M.mulatta glutamate receptor, ionotropic, AMPA 2		XP_001095129.2 940 aa
	GRIA2, C.lupus glutamate receptor, ionotropic, AMPA 2		XP_539784.2 895 aa
	GRIA2, B.taurus glutamate receptor, ionotropic, AMPA 2		NP_001069789.2 883 aa
	Gria2, M.musculus glutamate receptor, ionotropic, AMPA2 (alpha 2)		NP_001077275.1 883 aa
	Gria2, R.norvegicus glutamate receptor, ionotropic, AMPA 2		NP_058957.1 883 aa
	GRIA2, G.gallus glutamate receptor, ionotropic, AMPA 2		NP_001001775.2 883 aa
	gria2b, D.rerio glutamate receptor, ionotropic, AMPA 2b		NP_571970.2 879 aa
	gria2a, D.rerio glutamate receptor, ionotropic, AMPA 2a		NP_571969.1 875 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

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Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

PubMed Articles associated with genes and sequences of this homology group.
The structure of (-)-kaitocephalin bound to the ligand binding domain of the (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/glutamate receptor, GluA2. Ahmed AH, et al. J Biol Chem 287, 41007-13 (2012).
Identification of differentially expressed genes according to chemosensitivity in advanced ovarian serous adenocarcinomas: expression of GRIA2 predicts better survival. Choi CH, et al. Br J Cancer 107, 91-9 (2012).
Synaptic distributions of GluA2 and PKMζ in the monkey dentate gyrus and their relationships with aging and memory. Hara Y, et al. J Neurosci 32, 7336-44 (2012).
Calcium-permeable AMPA receptors provide a common mechanism for LTP in glutamatergic synapses of distinct hippocampal interneuron types. Szabo A, et al. J Neurosci 32, 6511-6 (2012).
Rapid glutamate receptor 2 trafficking during retinal degeneration. Lin Y, et al. Mol Neurodegener 7, 7 (2012).
Molecular dynamics simulations for glutamate-binding and cleft-closing processes of the ligand-binding domain of GluR2. Okada O, et al. Biophys Chem 162, 35-44 (2012).
GluA2 AMPA glutamate receptor subunit exhibits codon 607 Q/R RNA editing in the lens. Farooq M, et al. Biochem Biophys Res Commun 418, 273-7 (2012).
Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension. Li DP, et al. J Neurosci 32, 372-80 (2012).
Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Krintel C, et al. Biochem J 441, 173-8 (2012).
Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. Lussier MP, et al. J Neurosci 31, 3077-81 (2011).
See all (373)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
Lig_chan (pfam00060) Ligand-gated ion channel.
PBPb (cl15306) Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
Periplasmic_Binding_Protein_Type_1 (cl10011) Type 1 periplasmic binding fold superfamily.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:95809 Orthology group for M.musculus Gria2 includes H.sapiens GRIA2 and R.norvegicus Gria2.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Chordata*
Actinopterygii - bony fishes (26 transcripts, 7 species)
Mammalia - mammals (18 transcripts, 12 species)
Aves - birds (9 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
*Annelida*
Hirudinida - segmented worms (4 transcripts, 1 species)
*Arthropoda*
Insecta - insects (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
*Mollusca*
Gastropoda - gastropods (3 transcripts, 1 species)

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