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HomoloGene:12998. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TRAF7,  H.sapiens
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
    NP_115647.2
670 aa
   TRAF7,  P.troglodytes
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
    XP_001162318.1
670 aa
   TRAF7,  M.mulatta
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
    XP_001083720.1
670 aa
   TRAF7,  C.lupus
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
    XP_005621783.1
670 aa
   TRAF7,  B.taurus
TNF receptor-associated factor 7
    NP_001019692.1
669 aa
   Traf7,  M.musculus
TNF receptor-associated factor 7
    NP_001165584.1
669 aa
   Traf7,  R.norvegicus
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
    NP_001121020.1
669 aa
   TRAF7,  G.gallus
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
    NP_001012546.1
655 aa
   traf7,  X.tropicalis
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
    NP_001135502.1
666 aa
   traf7,  D.rerio
TNF receptor-associated factor 7
    NP_001073654.1
639 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations.
Reuss DE, et al. Acta Neuropathol 125, 351-8 (2013).
The seventh ring: exploring TRAF7 functions.
Zotti T, et al. J Cell Physiol 227, 1280-4 (2012).
TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation.
Morita Y, et al. Mol Biol Cell 16, 5433-44 (2005).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-TRAF (pfam02176)
  TRAF-type zinc finger.
zf-C3HC4_2 (pfam13923)
  Zinc finger, C3HC4 type (RING finger).
DD_cGKI (cl17044)
  Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I.
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
zf-TRAF (pfam02176)
  TRAF-type zinc finger.
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Traf7 includes H.sapiens TRAF7 and R.norvegicus Traf7.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 12 species)
Actinopterygii - bony fishes (13 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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