HomoloGene Result

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HomoloGene:114397. Gene conserved in Coelomata

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.		Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	BPTF, H.sapiens bromodomain PHD finger transcription factor		NP_872579.2 2920 aa
	BPTF, P.troglodytes bromodomain PHD finger transcription factor		XP_003315737.1 2917 aa
	Bptf, M.musculus bromodomain PHD finger transcription factor		NP_789820.2 2921 aa
	BPTF, G.gallus bromodomain PHD finger transcription factor		XP_003642377.1 2896 aa
	wu:fc30e02, D.rerio wu:fc30e02		XP_001920272.1 2758 aa
	E(bx), D.melanogaster Enhancer of bithorax		NP_001163305.1 2139 aa
	AgaP_AGAP006133, A.gambiae AGAP006133-PA		XP_316196.4 2782 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

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Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*M.musculus*
MP:0003012 No phenotypic analysis. No description of morphological, physiological or behavioral information presented.
MP:0005378 Growth/size phenotype.
MP:0005380 Embryogenesis phenotype.
MP:0010768 Mortality/aging. Characteristics involving the ability of an organism to live and age normally throughout development and life span.

PubMed Articles associated with genes and sequences of this homology group.
Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Ruthenburg AJ, et al. Cell 145, 692-706 (2011).
A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype. Buganim Y, et al. PLoS One 5, e9657 (2010).
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Li H, et al. Nature 442, 91-5 (2006).
Altered expression and distribution of FAC1 during NGF-induced neurite outgrowth of PC12 cells. Rhodes J, et al. Neuroreport 14, 449-52 (2003).
GAL4 directs nucleosome sliding induced by NURF. Kang JG, et al. EMBO J 21, 1406-13 (2002).
Altered subcellular distribution of transcriptional regulators in response to Abeta peptide and during Alzheimer's disease. Jordan-Sciutto K, et al. Mech Ageing Dev 123, 11-20 (2001).
Identification and characterization of BPTF, a novel bromodomain transcription factor. Jones MH, et al. Genomics 63, 35-9 (2000).
Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator. Jordan-Sciutto KL, et al. J Biol Chem 274, 35262-8 (1999).
DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation. Jordan-Sciutto KL, et al. Biochem Biophys Res Commun 260, 785-9 (1999).
FAC1 expression and localization in motor neurons of developing, adult, and amyotrophic lateral sclerosis spinal cord. Mu X, et al. Exp Neurol 146, 17-24 (1997).
See all (80)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
Trichoplein (pfam13868) Tumour suppressor, Mitostatin.
Bromodomain (cl02556) Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
DDT (cl02674) DDT domain.
RING (cl15348) RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:2444008 Orthology group for M.musculus Bptf includes H.sapiens BPTF.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Chordata*
Mammalia - mammals (23 transcripts, 8 species)
Actinopterygii - bony fishes (10 transcripts, 6 species)
Amphibia - amphibians (7 transcripts, 2 species)
Ascidiacea - tunicates (5 transcripts, 2 species)
Aves - birds (4 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
*Arthropoda*
Insecta - insects (9 transcripts, 6 species)
Arachnida - arachnids (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)
*Mollusca*
Gastropoda - gastropods (4 transcripts, 2 species)
*Cnidaria*
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)
*Annelida*
Hirudinida - segmented worms (1 transcript, 1 species)

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