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HomoloGene is a system for automated detection of homologs among the annotated genes of several completely sequenced eukaryotic genomes.

HomoloGene Release 65 Statistics



Initial numbers of genes from complete genomes, numbers of genes placed in a homology group, and the numbers of groups for each species.

Species   Number of Genes   HomoloGene
  Input Grouped   groups
Homo sapiens 19,943* 18,981   18,431
Pan troglodytes 25,096  16,850   15,980
Canis familiaris 19,766  16,708   15,951
Bos taurus 22,049  18,180   16,224
Mus musculus 25,388  21,766   19,005
Rattus norvegicus 21,991  19,229   17,473
Gallus gallus 17,959  13,142   11,905
Danio rerio 26,690* 21,084   14,067
Drosophila melanogaster 13,827* 9,282   7,749
Anopheles gambiae 12,460  8,867   7,541
Caenorhabditis elegans 20,132* 8,678   4,810
Schizosaccharomyces pombe 5,043  3,225   2,935
Saccharomyces cerevisiae 5,880  4,851   4,370
Kluyveromyces lactis 5,335  4,459   4,382
Eremothecium gossypii 4,722  3,928   3,884
Magnaporthe grisea 12,832  7,330   6,399
Neurospora crassa 9,821* 6,287   6,144
Arabidopsis thaliana 27,309* 19,961   11,243
Oryza sativa 26,887  17,276   10,627
Plasmodium falciparum 5,266  1,862   799


'*' indicates organisms where new genome annotation data is used in this build.


Last updated on: Mon Feb 14 2011



We have recently adopted a new build procedure that makes use of amino acid sequence searching (blastp) to find more distant relationships, but the procedure still refers to the DNA sequence for computation of some of the statistics. The matching strategy is guided by the taxonomic tree such that more closely related organisms are compared first. Moreover, HomoloGene entries now include paralogs in addition to orthologs.




Sources of Additional Information



HomoloGene entries have been augumented with homology and phenotype information drawn from the following sources.

Online Mendelian Inheritance in Man (OMIM)

Mouse Genome Informatics (MGI)

Zebrafish Information Network (ZFIN)

Saccharomyces Genome Database (SGD)

FlyBase

 

What's New
HomoloGene release 65 includes updated annotations for the following species: Homo sapiens (NCBI release 37.2), Danio rerio (NCBI release 4.1), Drosophila melanogaster (NCBI release 9.3) Caenorhabditis elegans (NCBI release 9.1), Arabidopsis thaliana (NCBI release 9.1).



Related Resources
Protein Clusters

List of Genomes

Taxonomy