GTR Home > Tests > TPMT Genotyping

Overview

Test name

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TPMT Genotyping (TPMT)

Purpose of the test

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This is a clinical test intended for Help: Drug Response, Mutation Confirmation, Pre-symptomatic, Risk Assessment

Condition

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3 conditions tested. Click Indication tab for more information.

Methodology

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Molecular Genetics
TTargeted variant analysis
RT-PCR with gel analysis

Summary of what is tested

1 genes and variants. Click Methodology tab for more information.

Genes

Clinical validity

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Not provided

Clinical utility

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Not provided

How to order

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Complete the appropriate test requisiton and have it signed by the referring physician.
Order URL Help: http://www.cincinnatichildrens.org/service/d/diagnostic-labs/molecular-genetics/requisition/

Test services

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  • Clinical Testing/Confirmation of Mutations Identified Previously

Clinical resources

Practice guidelines

  • CPIC, 2013
    Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update
  • CPIC, 2011
    Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing
  • NACB, 2010
    National Academy of Clinical Biochemistry, Clinical practice considerations. In: Laboratory medicine practice guidelines: guidelines and recommendations for laboratory analysis and application of pharmacogenetics to clinical practice, 2010
  • Nguyen et al., 2011
    Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk

Consumer resources

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.