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NHEJ1 nonhomologous end-joining factor 1

Also known as: XLF

Summary

Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008]

Genomic context

Location:
2q35
Sequence:
Chromosome: 2; NC_000002.12 (219075324..219160865, complement)
Total number of exons:
8

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