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UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

Also known as: NDGOA; PARK5; PGP95; PGP9.5; Uch-L1; HEL-117; PGP 9.5

Summary

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]

Genomic context

Location:
4p14
Sequence:
Chromosome: 4; NC_000004.12 (41256881..41268429)
Total number of exons:
9

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