PRKCQ protein kinase C theta
Gene ID: 5588, updated on 5-Mar-2024Gene type: protein coding
Also known as: PRKCT; nPKC-theta
- See all available tests in GTR for this gene
- Go to complete Gene record for PRKCQ
- Go to Variation Viewer for PRKCQ variants
Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association study of bronchodilator response in asthmatics. GeneReviews: Not available | |
| Common variants at CD40 and other loci confer risk of rheumatoid arthritis. GeneReviews: Not available | |
| Genetics of rheumatoid arthritis contributes to biology and drug discovery. GeneReviews: Not available | |
| Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. GeneReviews: Not available | |
| Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. GeneReviews: Not available | |
| Genome-wide association study of antibody response to smallpox vaccine. GeneReviews: Not available | |
| Genome-wide association study of body mass index in 23 000 individuals with and without asthma. GeneReviews: Not available | |
| Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus. GeneReviews: Not available | |
| Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. GeneReviews: Not available |
Genomic context
- Location:
- 10p15.1
- Sequence:
- Chromosome: 10; NC_000010.11 (6394097..6580646, complement)
- Total number of exons:
- 21
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for PRKCQ variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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