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NDUFA13 NADH:ubiquinone oxidoreductase subunit A13

Also known as: B16.6; CDA016; CGI-39; GRIM19; GRIM-19

Summary

This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Hurthle cell carcinoma of thyroid
MedGen: C0749424OMIM: 607464GeneReviews: Not available
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Genomic context

Location:
19p13.2
Sequence:
Chromosome: 19; NC_000019.10 (19516210..19528204)
Total number of exons:
5

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