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NRAS neuroblastoma RAS viral (v-ras) oncogene homolog

Also known as: NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1


This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

Associated conditions

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Carcinoma of colon
MedGen: C0699790OMIM: 114500GeneReviews: Not available
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Epidermal nevus
MedGen: C0334082OMIM: 162900GeneReviews: Not available
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Giant pigmented hairy nevus
MedGen: C1842036OMIM: 137550GeneReviews: Not available
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Neurocutaneous melanosis
MedGen: C0544862OMIM: 249400GeneReviews: Not available
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Noonan syndrome 6
MedGen: C2750732OMIM: 613224GeneReviews: Noonan Syndrome
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RAS-associated autoimmune leukoproliferative disorder
MedGen: C2674723OMIM: 614470GeneReviews: Not available
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Thyroid cancer, follicular
MedGen: C0206682OMIM: 188470GeneReviews: Not available
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Genomic context

Chromosome: 1; NC_000001.11 (114704464..114716894, complement)
Total number of exons:


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