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NODAL nodal growth differentiation factor

Also known as: HTX5


The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 2008]

Copy number response

Copy number response

No evidence available (Last evaluated (2013-08-08)

ClinGen Genome Curation Page

Little evidence for dosage pathogenicity (Last evaluated (2013-08-08)

ClinGen Genome Curation PagePubMed

Genomic context

Chromosome: 10; NC_000010.11 (70431936..70441709, complement)
Total number of exons:


  • BioSystems
  • ClinVar
    Related medical variations
  • dbVar
    Link from Gene to dbVar
  • MedGen
    Related information in MedGen
  • NODAL database
  • OMIM
    Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
  • PubMed (OMIM)
    Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
  • RefSeq RNAs
    Link to Nucleotide RefSeq RNAs
  • RefSeqGene
    Link to Nucleotide RefSeqGenes
  • SNP: GeneView
    SNPs linked from GeneView

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