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MUTYH mutY DNA glycosylase

Also known as: MYH


This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Associated conditions

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MYH-associated polyposisCompare labs
Neoplasm of stomach
MedGen: C0038356OMIM: 613659GeneReviews: Not available
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MedGen: C0206711OMIM: 132600GeneReviews: Not available
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Genomic context

Chromosome: 1; NC_000001.11 (45329242..45340470, complement)
Total number of exons:


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