IL2 interleukin 2
Gene ID: 3558, updated on 10-Mar-2024Gene type: protein coding
Also known as: IL-2; TCGF; lymphokine
- See all available tests in GTR for this gene
- Go to complete Gene record for IL2
- Go to Variation Viewer for IL2 variants
Summary
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020]
Associated conditions
See all available tests in GTR for this gene
Description | Tests |
---|---|
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. GeneReviews: Not available | |
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. GeneReviews: Not available | |
Genetics of rheumatoid arthritis contributes to biology and drug discovery. GeneReviews: Not available | |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. GeneReviews: Not available | |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. GeneReviews: Not available | |
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. GeneReviews: Not available | |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. GeneReviews: Not available | |
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus. GeneReviews: Not available | |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. GeneReviews: Not available | |
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. GeneReviews: Not available | |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. GeneReviews: Not available | |
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. GeneReviews: Not available | |
Multiple common variants for celiac disease influencing immune gene expression. GeneReviews: Not available | |
Newly identified genetic risk variants for celiac disease related to the immune response. GeneReviews: Not available |
Genomic context
- Location:
- 4q27
- Sequence:
- Chromosome: 4; NC_000004.12 (122451470..122456725, complement)
- Total number of exons:
- 4
Variation
Resource | Links for this gene |
---|---|
ClinVar | Variants reported to ClinVar |
dbVar | Studies and variants |
SNP | GeneView ReportGo to Variation Viewer for IL2 variants |
1000 Genomes | See 1000 Genomes Browser (GRCh37.p13) |
- BioSystemsBioSystems
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- IL2 @ LOVD
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- SNP: GeneViewSNPs linked from GeneView
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