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FLT3 fms-related tyrosine kinase 3

Also known as: FLK2; STK1; CD135; FLK-2

Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Acute lymphoid leukemia
MedGen: C0023449OMIM: 613065GeneReviews: Not available
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Genomic context

Location:
13q12
Sequence:
Chromosome: 13; NC_000013.11 (28003274..28100592, complement)
Total number of exons:
24

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