AKT2 AKT serine/threonine kinase 2
Gene ID: 208, updated on 19-Sep-2024Gene type: protein coding
Also known as: PKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA
- See all available tests in GTR for this gene
- Go to complete Gene record for AKT2
- Go to Variation Viewer for AKT2 variants
Summary
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]
Associated conditions
Copy number response
Description |
---|
Copy number response Haploinsufficency No evidence available (Last evaluated 2015-05-07) ClinGen Genome Curation PageTriplosensitivity No evidence available (Last evaluated 2015-05-07) ClinGen Genome Curation Page |
Genomic context
- Location:
- 19q13.2
- Sequence:
- Chromosome: 19; NC_000019.10 (40230317..40285345, complement)
- Total number of exons:
- 14
Variation
Resource | Links for this gene |
---|---|
ClinVar | Variants reported to ClinVar |
dbVar | Studies and variants |
SNP | Variation Viewer for AKT2 variants |
Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- AKT2 database
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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