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DCC DCC netrin 1 receptor

Also known as: CRC18; CRCR1; MRMV1; IGDCC1; NTN1R1


This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

Associated conditions

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Carcinoma of colon
MedGen: C0699790OMIM: 114500GeneReviews: Not available
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Malignant tumor of esophagus
MedGen: C0546837OMIM: 133239GeneReviews: Not available
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Mirror movements, congenital
MedGen: C1834870OMIM: 157600GeneReviews: Not available
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Genomic context

Chromosome: 18; NC_000018.10 (52340172..53535903)
Total number of exons:


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