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COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)

Also known as: VIIAL; COX7AL; COX7AL1; COXVIIAL; COXVIIa-L

Summary

Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]

Genomic context

Location:
6q12
Sequence:
Chromosome: 6; NC_000006.12 (75237675..75243928, complement)
Total number of exons:
4

Links

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  • RefSeq RNAs
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  • SNP: GeneView
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  • SNP: Genotype
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