GTR Home > Conditions/Phenotypes > Neuroblastoma 3

Disease characteristics

Excerpted from the GeneReview: ALK-Related Neuroblastoma Susceptibility
ALK-related neuroblastoma susceptibility occurs in individuals who are heterozygous for a germline ALK mutation and is characterized by an increased risk of developing neuroblastoma, ganglioneuroblastoma, or ganglioneuroma. The risk for tumor development is highest in infancy and decreases by late childhood. Individuals with familial neuroblastoma tend to develop tumors at a younger age (average 9 months) than those without familial predisposition (age 2-3 years).

Associated genes

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