GTR Home > Conditions/Phenotypes > Parietal foramina

Disease characteristics

Excerpted from the GeneReview: Enlarged Parietal Foramina
Enlarged parietal foramina are characteristic symmetric, paired radiolucencies of the parietal bones, located close to the intersection of the sagittal and lambdoid sutures, caused by deficient ossification around the parietal notch, which is normally obliterated by the fifth month of fetal development. Enlarged parietal foramina are usually asymptomatic. Meningeal, cortical, and vascular malformations of the posterior fossa occasionally accompany the bone defects and may predispose to epilepsy. In a minority of individuals, headaches, vomiting, or intense local pain are sometimes associated with the defects, especially on application of mild pressure to the unprotected cerebral cortex.

Associated genes

Clinical features

  • Aplasia cutis congenita of scalp
  • Symmetrical, oval parietal bone defects
  • Seizure
  • Headache
  • Cleft palate
  • Cleft upper lip
  • Encephalocele
  • Parietal foramina
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