GTR Home > Conditions/Phenotypes > Spastic paraplegia 8

Disease characteristics

Excerpted from the GeneReview: Spastic Paraplegia 8
Hereditary spastic paraplegia 8 (SPG8) is a pure hereditary spastic paraplegia characterized by slowly progressive spastic paraplegia of the lower limbs (i.e., hyperreflexia and clonus) with onset between ages 18 and 59 years (average: 37.2 years in one study). Other findings can include weakness with muscle wasting of the lower limbs, urinary urgency, and decreased vibration sense. Affected individuals often become wheelchair dependent.

Available tests

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Associated genes

Clinical features

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  • Babinski sign
  • Urinary urgency
  • Hyperreflexia
  • Spastic gait
  • Lower limb spasticity
  • Upper limb spasticity
  • Urinary bladder sphincter dysfunction
  • Degeneration of the lateral corticospinal tracts
  • Spastic paraplegia
  • Urinary incontinence
  • Pes cavus
  • Impaired vibration sensation in the lower limbs
  • Lower limb muscle weakness
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