GTR Home > Conditions/Phenotypes > Spastic paraplegia 8

Disease characteristics

Excerpted from the GeneReview: Spastic Paraplegia 8
Hereditary spastic paraplegia 8 (SPG8) is a pure hereditary spastic paraplegia characterized by slowly progressive spastic paraplegia of the lower limbs (i.e., hyperreflexia and clonus) with onset between ages 18 and 59 years (average: 37.2 years in one study). Other findings can include weakness with muscle wasting of the lower limbs, urinary urgency, and decreased vibration sense. Affected individuals often become wheelchair dependent.

Available tests

10 tests are in the database for this condition. Compare labs offering these tests.

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Associated genes

Clinical features

  • Babinski sign
  • Urinary urgency
  • Hyperreflexia
  • Spastic gait
  • Lower limb spasticity
  • Upper limb spasticity
  • Urinary bladder sphincter dysfunction
  • Degeneration of the lateral corticospinal tracts
  • Spastic paraplegia
  • Urinary incontinence
  • Pes cavus
  • Impaired vibration sensation in the lower limbs
  • Lower limb muscle weakness
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