GTR Home > Conditions/Phenotypes > Corneal dystrophy, fuchs endothelial, 2

Summary

Late-onset Fuchs endothelial corneal dystrophy (FECD) is a degenerative disorder affecting roughly 4% of the population older than 40 years. It is distinguished from other corneal disorders by the progressive formation of guttae, which are microscopic refractile excrescences of the Descemet membrane, a collagen-rich basal lamina secreted by the corneal endothelium. From onset, it usually takes 2 decades for FECD to impair endothelial cell function seriously, leading to stromal edema and impaired vision (Sundin et al., 2006). [from OMIM]

Clinical features

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  • Edema
  • Corneal degeneration
  • Corneal guttata

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