GTR Home > Conditions/Phenotypes > Parkinson disease 4

Disease characteristics

Excerpted from the GeneReview: Parkinson Disease Overview
Parkinsonism refers to all clinical states characterized by tremor, muscle rigidity, slowed movement (bradykinesia) and often postural instability. Parkinson disease is the primary and most common form of parkinsonism. Psychiatric manifestations, which include depression and visual hallucinations, are common but not uniformly present. Dementia eventually occurs in at least 20% of cases. The most common sporadic form of Parkinson disease manifests around age 60; however, young-onset and even juvenile presentations are seen.

Available tests

1 test is in the database for this condition. See lab offering the test.

Check Associated genes and Related conditions for additional relevant tests.

Associated genes

  • Also known as: NACP, PARK1, PARK4, PD1, SNCA
    Summary: synuclein, alpha (non A4 component of amyloid precursor)

Clinical features

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  • Orthostatic hypotension
  • Hallucinations
  • Dementia
  • Parkinsonism
  • Weight loss
  • Dysautonomia
  • Lewy bodies
  • Paranoia
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